Comparative Study of Midazolam and Diazepam as an Anesthesia Induction Agent / 대한마취과학회지

ABSTRACT

Midazolam maleate, a water solule benzodiazepine unlike diazepam, was synthetized by Walser and Fryer in 1975. In order to evaluate the effectiveness as an induction agent for general anesthesia, 22 elective surgical patients belonging to ASA classification 1 and 2 were selected. And ten patients(male 7, female 3, average 33.5 years old) were induced with midazolam maleate 0.2mg/kg and twelve patients (male7, female 5, averaged 32.5 years old) with diazepam 0.4mg/kg. The results were summarized as follows. 1) Anesthesia was induced in all of midazolam group by one intravenous injection, but only 6 patients of diazepam group could induced by one injection and the other 6 patients needed 2 or more injections. 2) The changes of blood pressure and pulse rate after induction and intubation were almost similar in the two groups, but greater individual variation was seen in diazepam group. 3) A buring sensation following intravenous injection was noted in 11 cases of diazepam group, but none in midazolam group and no phlebitis in either group. From the above resutls, diazepam and midazolam are almost similar in nature but midazolam is definitely effective as an induction agent and has less isde effects. Therefore midazolam maleate is regraded as a more effective agent than diazepam as an induction for general anesthesia.