Interaction between Inorganic Mercury and Selenium on Tissue Sulfhydryl Groups and Glutathione-linked Enzymes in Rats
Yonsei Medical Journal
; : 122-126, 1981.
Article
em En
| WPRIM
| ID: wpr-225819
Biblioteca responsável:
WPRO
ABSTRACT
The effect of selenium on the tissue sulfhydryl group content and lipid peroxide-destorying enzyme system in the liver, kidney and testis of rat treated with mercury was investigated. The male rats were injected s.c. with HgCl2 (10 micromoles/kg BW) and orally received Na2SeO3 (13 micromoles/kg BW) simultaneously. After 3 days, liver, kidney and testis were removed and analyzed. Mercury decreased the total sulfhydryl group content in the kidney by 25% and the total glutathione content in the kidney and testis by 50% and 36%, respectively, with no changes in other tissues. There was 12% increase in the total sulfhydryl group but not in the total glutathione content in kidney by a simul-taneous treatment of Se and Hg. Glutathione peroxidase (GSH-Px) activities were decreased by 63% in the liver and 69% in the kidney, and glutathione reductase (GSH-Rd) activity was increased in the tests by 16% by the Hg treatment with no changes in Other tissues. Hg had no effect upon glutathione-S-transferase activities in all organs examined. Simultaneous Se treatment increased GSH-Rd activity in the kidney by 23% and GSH-Px activities in liver and kidney by 24% and 21%, respectively, compared to the Hg-treated group. These data indicate that the alleviation of Hg toxicity by Se treatment is well correlated with the protein sulfhydryl group content and GSH-Px activity.
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Base de dados:
WPRIM
Assunto principal:
Selênio
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Compostos de Sulfidrila
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Glutationa
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Glutationa Peroxidase
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Glutationa Redutase
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Animais
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Mercúrio
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article