Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues
Journal of Korean Medical Science
; : 313-316, 2001.
Article
em En
| WPRIM
| ID: wpr-228346
Biblioteca responsável:
WPRO
ABSTRACT
The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Estômago
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Tiroxina
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Álcool Desidrogenase
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Tireotoxicose
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Ratos Sprague-Dawley
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Mucosa Gástrica
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Rim
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Fígado
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Pulmão
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Animais
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article