Study on the efficacy of hepatitis B virus vaccination and its influencing factors among children in rural area of Jiangsu province / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 322-325, 2007.
Article
em Zh
| WPRIM
| ID: wpr-232312
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy of hepatitis B viruse (HBV) vaccination and its influencing factors among children in rural area of Jiangsu province.</p><p><b>METHODS</b>Twenty-five hundred and twenty-two children born after 1998 in rural area were selected as the study population using multistage cluster sampling method. HBsAg and anti-HBs were detected by enzyme linked immunoassay (ELISA) and radio-immunoassay (RIA), respectively. Anti-HBs negative children were boosted using different hepatitis B vaccines and the efficacy was compared. Factors causing HBV infection in HBsAg positive children were also investigated.</p><p><b>RESULTS</b>HBsAg positive rates in 1-7 year olds were 0.28%-1.28%, and the anti-HBs positive rates decreased from 76.7% to 45.5%. The HBsAg positive rate in children not timely vaccinated was significantly higher than those with HBV vaccine injection within 24 hours after birth (1.4% vs. 0.5%, P = 0.031). More than 90% of the anti-HBs negative children had protective level of anti-HBs after boosted with HBV vaccine.</p><p><b>CONCLUSION</b>HBsAg positive rate in children born after 1998 in rural area of Jiangsu province decreased significantly, with an average of 0.8%. The reason for HBsAg carriage in children might be attributed to mother-to-infant transmission or not timely HBV vaccination.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
População Rural
/
Sangue
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China
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Epidemiologia
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Vacinas contra Hepatite B
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Transmissão Vertical de Doenças Infecciosas
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Alergia e Imunologia
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Hepatite B
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Antígenos de Superfície da Hepatite B
Limite:
Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
/
Pregnancy
País como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2007
Tipo de documento:
Article