Progress in research of molecular mechanisms of pulmonary arterial smooth muscle cell proliferation / 南方医科大学学报
Journal of Southern Medical University
; (12): 1852-1855, 2013.
Article
em Zh
| WPRIM
| ID: wpr-232686
Biblioteca responsável:
WPRO
ABSTRACT
Pulmonary hypertension (PAH) is a common clinical syndrome characterized by elevated pulmonary arterial pressure. The pathological changes in PAH include increased vasoconstrictor tone, thrombosis in situ and pulmonary vascular remodeling. Pulmonary arterial smooth muscle cell (PASMC) proliferation is a hallmark of pulmonary vascular remodeling, and exploration of the molecular mechanisms of PASMC proliferation and intervention of the involved signaling pathways is therefore of great importance for prevention and treatment of PAH. This review focus primarily on the current understanding of the molecular mechanisms involved in the proliferation of PASMCs.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Artéria Pulmonar
/
Transdução de Sinais
/
Biologia Celular
/
Miócitos de Músculo Liso
/
Proliferação de Células
/
Remodelação Vascular
/
Hipertensão Pulmonar
/
Pulmão
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article