Gene frequencies of 4 STR loci in Tibetan population of Yunnan province / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the gene frequencies of 4 STR loci in Tibetan population of Yunnan.</p><p><b>METHODS</b>Multiple polymerase chain reaction (PCR), denaturing polyacrylamide gel electrophoresis and silver staining were used to detect D21S11, D8S1179, D16S539 and LPL loci. DNA samples collected from 105 unrelated Tibetan individuals in Yunnan province were analyzed.</p><p><b>RESULTS</b>At D21S11, D8S1179, D16S539 and LPL loci, 13, 8, 7, 6 alleles and 33, 21, 16 and 9 genotypes were observed, respectively. The genotype distribution of the 4 STR was in accordance with the Hardy-Weinberg equilibrium.</p><p><b>CONCLUSION</b>The high combined discrimination power and exclusion power of the four loci in Tibetan population make multi-PCR detection a valuable tool for forensic identity, genetics and anthropology.</p>