Limited sampling strategy models for estimating AUC for amlodipine in Chinese healthy volunteers / 药学学报
Acta Pharmaceutica Sinica
; (12): 1582-1586, 2010.
Article
em Zh
| WPRIM
| ID: wpr-250591
Biblioteca responsável:
WPRO
ABSTRACT
This study aims to save cost of sampling for estimating the area under the amlodipine plasma concentration versus time curve in 24 hours (AUC(0-24 h)). Limited sampling strategy (LSS) models was developed and validated by mutiple regression model within 4 or fewer amlodipine concentration values. Absolute prediction error (APE), root of mean square error (RMSE) and visual predict check were used as criterion. The results of Jackknife validation showed that fifteen (9.4%) of the 160 LSS based on regression analysis were not within an APE of 15% by using one concentration-time point. 156 (97.5%), 159 (99.4%) and 160 (100%) of the 160 LSS model were capable of predicting within an APE 15% by using 2, 3, 4 points, separately. Limited sampling strategies have been developed and validated for estimating AUC(0-24 h) of amlodipine. The present study indicated that the implemention of both 5 mg and 10 mg dosage could enable accurate predictions of AUC(0-24 h) by the same LSS model. This study shows that 12, 4, 24, 2 h after administration are key sampling time points. The combination of (12, 4), (12, 4, 24) or (12, 4, 24, 2 h) might be chosen as sampling hours for predicting AUC(0-24 h) in practical application according to requirement.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Vasodilatadores
/
Sangue
/
Farmacocinética
/
Bloqueadores dos Canais de Cálcio
/
Administração Oral
/
Análise de Regressão
/
Anlodipino
/
Tamanho da Amostra
/
Área Sob a Curva
/
Povo Asiático
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2010
Tipo de documento:
Article