Chemical constituents from Morus notabilis and their cytotoxic effect / 药学学报
Yao Xue Xue Bao
; (12): 579-582, 2015.
Article
em Zh
| WPRIM
| ID: wpr-257098
Biblioteca responsável:
WPRO
ABSTRACT
Une new flavonoids named as notabilisin K (1), together with four known compounds, morusin (2), mulberrofuran A (3), neocyclomorusin (4) and mornigrol F (5) are separated from 95% ethanol extracts of the twigs of Morus notabilis. Compounds 2-5 are separated from this plant for the first time. Notabilisin I, notabilisin J exhibits certain effect against cells of HCT-116, HepG2 and A2780 with IC50 values ranging from 1.47 μmol x L(-1) to 5.46 μmol x L(-1). Morusin exhibits strong effect against five kinds of human cancer cells (BGC823, A2780, HCT-116, HepG2 and NCI-H1650) with IC50 values ranging from 0.74 μmol x L(-1) to 1.58 μmol x L(-1).
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Terpenos
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Benzofuranos
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Flavonoides
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Extratos Vegetais
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Química
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Concentração Inibidora 50
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Morus
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Células Hep G2
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Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article