Advancement of insulin effecting signaling pathway of leukemia cell proliferation / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 514-517, 2012.
Article
em Zh
| WPRIM
| ID: wpr-263360
Biblioteca responsável:
WPRO
ABSTRACT
Many reports have documented a role of insulin and insulin-like growth factor 1 (IGF-1) as growth factors in many cancers. The sequence and structure of insulin receptor (IR) and IGF receptor (IGF-1R) are highly similar. Both receptors are overexpressed in leukemia cells.Studies indicate that insulin can enhance the signal of the phosphoinositide 3-kinase/Akt pathways by activating IR or IGF-1R or hybrid IR/IGF-IR receptors, resulting in the proliferation of leukemia cells. High concentration of insulin may inhibit the growth of leukemia cells, the mechanism of which remains to be unclear. Inhibiting IR and IGF-IR can diminish the proliferation of leukemia cells. Therefore, the assumption of IR/IGF-1R as a potential therapeutic target in leukemia appears reasonable. This article summarizes the recent advancement associated with the signaling pathway of insulin effecting the proliferation of leukemia cells.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Fator de Crescimento Insulin-Like I
/
Receptor de Insulina
/
Transdução de Sinais
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Leucemia
/
Linhagem Celular Tumoral
/
Proliferação de Células
/
Insulina
/
Metabolismo
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2012
Tipo de documento:
Article