With genechip technique to investigate HLA-DQB1 gene polymorphisms in south and north regions of China / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 238-239, 2006.
Article
em Zh
| WPRIM
| ID: wpr-263806
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To research and compare HLA-DQB1 gene frequency(GF) and polymorphism distribution between south and north population of Chinese in China.</p><p><b>METHODS</b>Combining PCR-sequence specific primers(SSP) and sequence specific oligonucleotide probe(SSOP) techniques and DNA Microarray Kit for HLA-DQB1 Low Res Genotyping from Shenzhen Yi-Shengtang Biological LTD. Co. was used to type HLA-DQB1 gene polymorphisms of 700 individuals living in south China and 320 individuals in north China.</p><p><b>RESULTS</b>We inspected 10 alleles of HLA-DQB1 and got a series of comprehensive and accurate statistic data.</p><p><b>CONCLUSION</b>It is tested that HLA-DQB1*02, 05, 0601, 0602, 0603 gene frequencies are different obviously(P<0.05) between south and north Chinese. And those data will be useful to kinds of research associated with disease relevant and anthropology research.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
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Variação Genética
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Sondas de Oligonucleotídeos
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Antígenos HLA-DQ
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China
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Reação em Cadeia da Polimerase
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Análise de Sequência de DNA
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Análise de Sequência com Séries de Oligonucleotídeos
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Povo Asiático
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Alelos
Limite:
Female
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Humans
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Male
País como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article