Clinical Analysis on Treatment of Chronic Myelomonocytic Leukemia with Allogeneic Hematopoietic Stem Cell Transplantation / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1667-1672, 2015.
Article
em Zh
| WPRIM
| ID: wpr-272541
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze retrospectively the therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for chronic myelomonocytic leukemia (CMML).</p><p><b>METHODS</b>The engraftment, graft versus host disease (GVHD), infection, relapse, and survival of 13 CMML patients received allo-HSCT were observed. The clinical outcome of allo-HSCT for CMML was analyzed.</p><p><b>RESULTS</b>Thirteen (10 males and 3 females) CMML patients with a median age of 38 years old received allo-HSCT including 4 from HLA-matched unrelated donors, 6 from HLA-matched sibling donors and 3 from haploidentical related donors. All 13 patients achieved engraftment, and the median time of neutrophil engraftment and platelet engraftment were 12 (11-18) days and 15 (10-55) days respectively, acute GVHD occurred in 8 patients. After the median follow-up of 13 (6-29) months, the overall survival, disease free survival and relapse were 53.8%, 53.8%, 7.7%, respectively.</p><p><b>CONCLUSION</b>Allo-HSCT can improve the survival of patients with CMML, and is a effective method for treatment of CMML.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Doadores de Tecidos
/
Transplante Homólogo
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Leucemia Mielomonocítica Crônica
/
Estudos Retrospectivos
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Transplante de Células-Tronco Hematopoéticas
/
Intervalo Livre de Doença
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Irmãos
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Doença Enxerto-Hospedeiro
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
/
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article