A study on HLA-DQB1 allele associated with genetic susceptibility to duodenal ulcer in Guangdong Hans / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 440-442, 2006.
Article
em Zh
| WPRIM
| ID: wpr-285105
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the genetic susceptibility of HLA-DQB1 alleles to duodenal ulcer in Chinese Hans from Guangdong area around.</p><p><b>METHODS</b>Hundred and five patients with duodenal ulcer and hundred and five healthy controls were examined for HLA-DQB1 genotypes. HLA-DQB1 allele typing was carried out by polymerase chain reaction with sequence specific primers (PCR-SSP).</p><p><b>RESULTS</b>The allele frequency of HLA-DQB1*0602 in patients with duodenal ulcer (64.8%) was significantly higher than that in healthy controls (14.3%).</p><p><b>CONCLUSION</b>These findings suggest that HLA-DQB1*0602 is a susceptible gene to duodenal ulcer in Guangdong Hans of China. And at HLA-DQB1 site, there are immunogenetic differences between duodenal ulcer patients and healthy controls.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Glicoproteínas de Membrana
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Antígenos HLA-DQ
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China
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Reação em Cadeia da Polimerase
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Predisposição Genética para Doença
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Povo Asiático
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Úlcera Duodenal
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Alelos
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Etnologia
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Cadeias beta de HLA-DQ
Limite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
País como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2006
Tipo de documento:
Article