Influence of MDR1 gene C3435T on peripheral white blood cell counts in workers exposed to benzene / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 20-23, 2011.
Article
em Zh
| WPRIM
| ID: wpr-293766
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effects of MDR1 C3435T on the peripheral white blood cell counts in workers exposed to benzene.</p><p><b>METHODS</b>One hundred and twenty-one benzene-exposed workers and 110 healthy controls without benzene exposure were enrolled in this study. White blood cell counts influenced by the polymorphism of MDR1 gene were analyzed.</p><p><b>RESULTS</b>The frequency of MDR1 3435 C/C, C/T, T/T in healthy controls was 37.27%, 46.36%, 16.37%, respectively, and it was 38.84%, 41.33%, 19.83% in the benzene-exposed workers, respectively. The frequency of the MDR1 gene was also not significantly different between benzene exposed workers and controls. Subjects exposed to benzene with MDR1 3435 mutation genotype (T/T) had the significantly lower WBC [(5.46 ± 1.51) × 10(9)/L] than those carrying wild type (C/C) and heterozygous (C/T), whose WBC were (6.08 ± 1.28) × 10(9)/L (P = 0.044).</p><p><b>CONCLUSION</b>P-glycoprotein encoded by MDR1 gene may be implicated into the hematotoxicity of benzene. Subjects carrying MDR1 3435 T/T genotype may have a higher risk of benzene poisoning.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Benzeno
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Grupos Controle
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Exposição Ocupacional
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Membro 1 da Subfamília B de Cassetes de Ligação de ATP
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Subfamília B de Transportador de Cassetes de Ligação de ATP
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Polimorfismo de Nucleotídeo Único
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Genética
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Genótipo
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Contagem de Leucócitos
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article