Role of autophagy in acute myeloid leukemia therapy / 癌症
Chinese Journal of Cancer
; (12): 130-135, 2013.
Article
em En
| WPRIM
| ID: wpr-295849
Biblioteca responsável:
WPRO
ABSTRACT
Despite its dual role in determining cell fate in a wide array of solid cancer cell lines, autophagy has been robustly shown to suppress or kill acute myeloid leukemia cells via degradation of the oncogenic fusion protein that drives leukemogenesis. However, autophagy also induces the demise of acute leukemia cells that do not express the known fusion protein, though the molecular mechanism remains elusive. Nevertheless, since it can induce cooperation with apoptosis and differentiation in response to autophagic signals, autophagy can be manipulated for a better therapy on acute myeloid leukemia.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Autofagia
/
Tretinoína
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Leucemia Mieloide Aguda
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Leucemia Promielocítica Aguda
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Proteínas de Fusão Oncogênica
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Apoptose
/
Usos Terapêuticos
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Tratamento Farmacológico
/
Proteínas Reguladoras de Apoptose
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article