Influence of hOCT1 polymorphism on imatinib mesylate effectiveness in chronic myelogenous leukemia patients / 中华血液学杂志
Chinese Journal of Hematology
; (12): 596-600, 2009.
Article
em Zh
| WPRIM
| ID: wpr-314454
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between hOCT1 polymorphism and imatinib mesylate (IM) effectiveness in chronic myelogenous leukemia(CML) patients, and to provide for the clinical individual personalized therapy.</p><p><b>METHODS</b>Fifty-three CML and 23 non-CML patients were enrolled in this study. Blood or bone marrow samples were collected. Amplification refractory mutation system (ARMS)-polymerase chain reaction was used to amplify the polymorphisms gene segment of hOCT1-P283L, R287G and M408V and their frequencies were statistically analysed. With clinical outcomes, the correlation between hOCT1 polymorphism and IM effectiveness in CML was analyzed.</p><p><b>RESULTS</b>(1) For 74 Han Chinese, the allele frequencies of hOCT1-P283L, R287G and M408V were 39.86%, 29.05% and 45.27%, respectively. (2) The genotypes of hOCT1-P283L, R287G and M408V in 2 Tibetan Chinese were CC, CC, AG and CC, CG, AG, respectively. (3) In the CML patients with IM optimal response, the frequencies of 283T and 287G allele were predominant (P<0.05). No significant difference was found in the frequency distribution of hOCT1-M408V genotype and allele among the 3 different response groups (P>0.05).</p><p><b>CONCLUSION</b>(1) Three single nucleotide polymorphisms (cSNP) P283L, R287G and M408V were found in the hOCT1 gene from 76 Chinese. (2) hOCT1 gene polymorphism is associated with the long-term molecular response of CML patients received IM therapy, indicating that the polymorphisms of hOCT1-283T, 287G may be good predictors for IM response. (3) There is no correlation between the polymorphisms of hOCT1-P283L, R287G, M408V and secondary IM resistance in CML patients.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Piperazinas
/
Polimorfismo Genético
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Pirimidinas
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Benzamidas
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Leucemia Mielogênica Crônica BCR-ABL Positiva
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Resultado do Tratamento
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Transportador 1 de Cátions Orgânicos
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Usos Terapêuticos
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Tratamento Farmacológico
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Mesilato de Imatinib
Tipo de estudo:
Prognostic_studies
Limite:
Female
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Humans
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Male
Idioma:
Zh
Ano de publicação:
2009
Tipo de documento:
Article