Biocompatibility, biodegradation, and neovascularization of human single-unit platelet-rich fibrin glue: an in vivo analysis / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 408-411, 2014.
Article
em En
| WPRIM
| ID: wpr-317970
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>The clinical applications of fibrin glue span over several surgical modalities. The aim of this study was to evaluate the biocompatibility and biodegradation of different formulations of platelet-rich fibrin glue in vivo and examine its effects on the neovascularization of wound sites.</p><p><b>METHODS</b>Human-derived single-unit fibrin glue was prepared. Incisions were made on the backs of rats, and these were coated with homemade glues containing different concentrations of aminomethylbenzoic acid (Groups A-F) or commercial adhesives (Group G). A sham control group was included (Group H). The wounds were examined by histological analysis and immunohistochemistry at several time points.</p><p><b>RESULTS</b>Successful wound closure was achieved in all groups by day 12. Acute inflammation occurred during the first six days, but gradually disappeared. The longest sealant duration was achieved using the lowest concentration of anti-fibrinolytic agent in a 110 volume ratio with cryoprecipitate. Expression levels of the platelet endothelial cell adhesion molecule-1 were significantly higher in Groups A and C compared to the control groups (Groups G and H) on day 3 (P < 0.05).</p><p><b>CONCLUSIONS</b>Single-unit platelet-rich fibrin glue has excellent biocompatibility and is associated with the upregulation of neovascularization. The addition of aminomethylbenzoic acid could prevent the degradation of fibrin glue.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Cicatrização
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Imuno-Histoquímica
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Adesivo Tecidual de Fibrina
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Ratos Sprague-Dawley
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Molécula-1 de Adesão Celular Endotelial a Plaquetas
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Usos Terapêuticos
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Metabolismo
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article