Association of Genetic Variations within 5' end of Neuregulin 1 with Schizophrenia in Korean Population / 신경정신의학
Journal of Korean Neuropsychiatric Association
; : 287-294, 2005.
Article
em Ko
| WPRIM
| ID: wpr-32633
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregulin 1 (NRG1) was identified in this locus as a positional and functional candidate gene for schizophrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRG1 is associated with schizophrenia in Korean population. METHODS: Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848, 420M9-1395) located at the 5' end of NRG1 were genotyped for 242 unrelated schizophrenia patients and the same number of normal controls. Genetic association was tested by chi2-test (df=1). Not only for the whole patients group but also for a subgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. RESULTS: G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, OR=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, OR=0.58) and five markers haplotype TTC53 (p=0.01, OR=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. CONCLUSION: NRG1 might either play a role in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Esquizofrenia
/
Variação Genética
/
Haplótipos
/
Desequilíbrio de Ligação
/
Repetições de Microssatélites
/
Neuregulina-1
/
Polimorfismo de Nucleotídeo Único
/
Povo Asiático
/
Alelos
/
Alucinações
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
Ko
Ano de publicação:
2005
Tipo de documento:
Article