An experirmental study on the preparation and drug sustained release characteristics of Pingyangmycin Albumin Microspheres / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 69-71, 2005.
Article
em Zh
| WPRIM
| ID: wpr-329982
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The aim of this study was to prepare Pingyangmycin Albumin Microspheres (PYM-AMS) for arteriovenous malformations treatment.</p><p><b>METHODS</b>PYM-AMS was prepared at 140 degrees C by the method of emulsification-heat solidification and its characteristics were evaluated, such as morphosis, particle size, drug loading (DL%), encapsulation efficiency (EE%), stability and drug sustained-releasing in vitro. After being packaged, PYM-AMS were sterilized with 13.7 kGy of 60Co. Small samples of PYM-AMS were packaged in small bottles and stored at 3 - 5 degrees C, 15 - 25 degrees C, 37 degrees C for 3 months, then checked the change of morphology, DL, EE and the release rate.</p><p><b>RESULTS</b>The surface of particles was smooth and integrated. The average diameter of PYM-AMS particles was 139.422 microm and 80% was in the range of 56 - 251 microm. The mean DL% and EE% were 26.47% and 84.3%, respectively. PYM released fast in 5 h, but then released slowly. 88.65% drugs were released in 24 h, and t50 was 1.5 h. There was no obvious change of the morphology, DL,EE and the release rate of PYM-AMS stored at 3 - 5 degrees C 15 - 25 degrees C, 37 degrees C for 3 months.</p><p><b>CONCLUSION</b>PYM-AMS prepared in this study had sustained-release effect, high drug loading and high stability. Albumin is a good carrier of PYM embolization agent.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Tamanho da Partícula
/
Bleomicina
/
Preparações de Ação Retardada
/
Albuminas
/
Microesferas
Idioma:
Zh
Ano de publicação:
2005
Tipo de documento:
Article