Effect of Shenxiong injection on inflammation injury of ischemia-reperfusion injury rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2408-2412, 2015.
Article
em Zh
| WPRIM
| ID: wpr-337920
Biblioteca responsável:
WPRO
ABSTRACT
To investigate the effect of Shenxiong injection on the inflammation injury of ischemia-reperfusion injury senile rats. Totally 84 Sprague-Dawley (SD) rats were randomly divided into six groups the sham operation group, the model group, the Nimodipine group and the Shenxiong injection(low, middle, and high dosage) groups. The rat cerebral ischemia-reperfusion model was established through intraperitoneal injection for 3 d and middle cerebral artery occlusion (MCAO). Ater the reperfusion for 24 h, efforts were made to give neurological score, collect brains for TTC staining, detect tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) content in serum by enzyme-linked immunosorbent assay (ELISA) method and measure IL-1β, ICAM-1 and MMP-9 mRNA expressions in hippocampal area by Real-time PCR (RT-PCR). According to the results, Shenxiong injection could decrease the cerebral infarction volume, greatly improved the neurological function and reduce IL-1β, TNF-α, ICAM-1 and MMP-9 mRNA expressions and IL-1β and TNF-α contents. In conclusion, Shenxiong injection shows the significant protective effect on ischemia-reperfusion injury in rats. Its mechanism may be related to the inhibition of inflammatory factor expression.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Medicamentos de Ervas Chinesas
/
Traumatismo por Reperfusão
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Interferon-alfa
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Ratos Sprague-Dawley
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Molécula 1 de Adesão Intercelular
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Metaloproteinase 9 da Matriz
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Tratamento Farmacológico
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Alergia e Imunologia
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Interleucina-1beta
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Genética
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
Zh
Ano de publicação:
2015
Tipo de documento:
Article