Effects of posttranslational modification on the activity of cytochrome P450: current progress / 药学学报
Acta Pharmaceutica Sinica
; (12): 487-492, 2011.
Article
em Zh
| WPRIM
| ID: wpr-348930
Biblioteca responsável:
WPRO
ABSTRACT
Regulation of the activity of CYP450 has always been research focus of drug metabolism. The effect of compounds on the mRNA and protein expression level of CYP450 is the main purpose of most of the existing reports. In recent years, the protein modification in the posttranslation level has been found to participate in maintaining the proper function of CYP450, thus effect of posttranslational modification on the enzyme activity has been paid more and more attention. Posttranslational modifications including phosphorylation, nitration, and ubiquitination have been described to regulate the activity of CYP450. In this paper, recent developments in the effects of posttranslational modifications on the activity of CYP450 have been reviewed.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Oxirredução
/
Fosforilação
/
Glicosilação
/
RNA Mensageiro
/
Processamento de Proteína Pós-Traducional
/
Sistema Enzimático do Citocromo P-450
/
Ubiquitinação
/
Genética
/
Metabolismo
/
Óxido Nítrico
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article