The protective effects of SB203580 against mortality and radiation induced intestinal injury of mice / 药学学报
Acta Pharmaceutica Sinica
; (12): 395-399, 2011.
Article
em Zh
| WPRIM
| ID: wpr-348942
Biblioteca responsável:
WPRO
ABSTRACT
This study is to investigate the protective effects of the SB203580 against radiation induced mortality and intestinal injury of mice. A total of 67 male C57BL/6 mice (20.0-22.0 g) were matched according to body weight and randomly assigned to one of three groups: control, total body irradiation exposure (IR, 7.2 Gy) only, and IR (7.2 Gy) + SB203580 (15 mg x kg(-1)). 30 days survival rate was observed in the experiment. In intestinal injury experiment, the expression levels of caspase-3, Ki67, p53 and p-p38 were assayed in the mice intestine crypts. The results showed that the 30 days survival rate was 100% (control), 0 (IR) and 40% (IR+ SB203580), separately. Compared to the IR groups, the positive cells of caspase-3, p53 and p-p38 in crypt cells decreased 33.00%, 21.78% and 34.63%, respectively. The rate of positive cells of Ki67 increased 37.96%. Significant difference was found between all of them (P < 0.01). SB203580 potently protected against radiation-induced lethal and intestinal injury in mice, and it may be a potential radio protector.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Piridinas
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Efeitos da Radiação
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Lesões Experimentais por Radiação
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Protetores contra Radiação
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Distribuição Aleatória
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Mortalidade
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Proteína Supressora de Tumor p53
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Irradiação Corporal Total
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2011
Tipo de documento:
Article