Progress in enhancing radiosensitivity by inhibition of DNA double strand break repair / 国际肿瘤学杂志

ABSTRACT

DNA double strand breaks are potentially lethal DNA lesions induced by ionizing radiation, which can be repaired by homologous recombination and non- homologous end joining. Inhibition of the expression and function of genes in double strand breaks repair pathways using RNA interference and anti- sense techniques could improve the radiosensitivity of cancer cells.