Your browser doesn't support javascript.
loading
Visfatin inhibits pancreatic β-cell line MIN6 apoptosis via PI3K-Akt and MAPK-ERK1/2 signaling pathways / 中华内分泌代谢杂志
Article em Zh | WPRIM | ID: wpr-389443
Biblioteca responsável: WPRO
ABSTRACT
To investigate the effects and the mechanism of visfatin on MIN6 cell signaling pathway and apoptosis induced by palmitate.Human recombinant visfatin promotes protein kinase B (Akt) and extracellularsignal regulating kinase (ERK)1/2 phosphorylation in dose-and time-dependent manner,and prevents MIN6 cell from apoptosis induced by palmitate (P<0.05 or P<0.01).The activation of Akt and ERK1/2 signaling pathway may be one of the molecular mechanisms of visfatin.
Palavras-chave
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Ano de publicação: 2010 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Ano de publicação: 2010 Tipo de documento: Article