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The influence of pretreatment with Anti-B lymphocyte serum on i mmunogenecity of islet preparations / 中国糖尿病杂志
Chinese Journal of Diabetes ; (12): 76-78, 2001.
Article em Zh | WPRIM | ID: wpr-411496
Biblioteca responsável: WPRO
ABSTRACT
Objective To investigate the influence of pretr eatment with anti-B lymphocyte serum on the immunogenecity and endocrine functi on of islet preparations.Methods Porcine ICCs were pretre ated with anti-B lymphocyte serum which was produced using the mixed adult porc i ne B lymphocyte as antigen.The immunogenecity of islet was measured by mixed isl et lymphocyte culture (MILC) and SLA-DR positive cell number within the islet and the islet function was assayed with insulin release test.Results  The cpm value of MILC of the group pretreated with anti-B lymphocy te serum and the MHCⅠ antigen and SLA-DR antigen positive cell numbers was mar kedly decreased in comparison with that of control group (P<0.001).There wa s no significant difference in insulin release of additional different groups.[ WT5”HZ Conclusion The pretreatment of islet preparation with anti -B lymphocyte serum may decrease the immunogenecity of islet preparation,while there is no marked influence on its insulin release function.
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Ano de publicação: 2001 Tipo de documento: Article
Texto completo: 1 Base de dados: WPRIM Idioma: Zh Ano de publicação: 2001 Tipo de documento: Article