Classification and Pathological Analysis of Immunophenotype of 76 Cases of Non-Hodgkin Lymphoma in Shenyang / 中国医科大学学报

ABSTRACT

Objective: Our aim was to discuss the pathological characteristics and immunophenotype of non-Hodgkin lymphoma (NHL) in Shenyang. Methods: Histopathological observation was performed with immunohistochemical methods (SP method). We used 10 antibodies as B,T markers to analyze 76 cases of NHL according to the new WHO classification. Results: The B-NHL was more prevalent than the T-NHL. In B-NHL, the Diffuse Large B cell Lymphoma (DLBL) was the most common, next was the mucosa-associated lymphoid tissue lymphoma (+/-monocytoid B-cells) and lymphoplasmacytic lymphoma (LPL). In T-NHL, the peripheral T cell lymphoma unspecificly accounted most. The positivity rates of CD79a in B-NHL were 100% and its cross-reactivity was 0. The straining rates of polyclonal CD3 with T cell were 88% and CD3 only reacted with 5% of B-NHL. Conclusion: The NHL in Shenyang was marked by the most common DLBL and peripheral T cell lymphoma, unspecificly. The rates of monocytoid lymphoma and LPL were higher. The CD79a and CD3 were antibodies of B-cell and T-cell markers with high sensitivity and specificity, respectively.