The changes and significance of integrin α4β7 and L-selectin levels in critical children / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine
; (36): 3-5, 2013.
Article
em Zh
| WPRIM
| ID: wpr-432847
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the changes ofintegrin α4β7 and L-selectin levels and the possible relationship between the changes and intestinal mucosal immune function in critical children with gastrointestinal dysfunction.Methods Forty-eight admitted critical children were divided into non-gastrointestinal dysfunction group (29 cases) and gastrointestinal dysfunction group (19 cases),and also compared with 25 healthy people (control group).The expression of integrin α 4β 7 and L-selectin was measured by flow cytometry.Results The expression of integrin α 4β 7 in gastrointestinal dysfunction group [(11.11 ± 1.15)%] was lower than that in non-gastrointestinal dysfunction group [(15.36 ± 1.26)%]and control group [(19.62 ±0.89)%] (P <0.05),but there was no significant difference between nongastrointestinal dysfunction group and control group(P > 0.05).The expression of L-selectin in gastrointestinal dysfunction group [(60.68 ±3.72)%] was lower than that in non-gastrointestinal dysfunction group [(69.43 ± 1.52)%] and control group [(88.65 ± 2.41)%] (P < 0.05),and there was significant difference between non-gastrointestinal dysfunction group and control group (P < 0.05).Conclusion The expression of integrin α 4β 7 and L-selectin is decreased at the early stage of gastrointestinal dysfunction in critical childern,and integrin α 4 β 7 is decreased sharply.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article