Notch signaling pathway and glioma stem cell niche / 国际肿瘤学杂志
Journal of International Oncology
; (12): 434-436, 2013.
Article
em Zh
| WPRIM
| ID: wpr-433151
Biblioteca responsável:
WPRO
ABSTRACT
A small fraction of tumor stem cells exist in glioma and play a key role in the tumorigenesis and propagation of glioma.They have a close relationship with their niche that offers structural and functional support.In glioma niche,vascular endothelial cells can provide Notch ligands for cancer stem cells to activate Notch signaling pathway and contact with other signaling pathways,maintaining the tumor stem cell self-renewal and increasing resistance of brain tumor stem cells to radiotherapy.Therefore,Notch signaling pathway is considered to be a new therapeutic target of glioma.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2013
Tipo de documento:
Article