Mammalian target of rapamycin and leukemia treatment / 白血病·淋巴瘤

ABSTRACT

mTOR exists in the variety of biological cells.The study showed in recent years that mTOR signaling pathway activation and tumor occurrence and development is closely related,and participate in many of the tumor cell proliferation and differentiation.including blood malignant tumora.Research shows that the inhibitor rapamycin and its derivatives,have anti-tumor effects.This reviewed the structure and function,signaling pathway of mTOR in the pathogenesis of leukemia the upper stream of the main adjustment factor and its inhibitors in the application of leukemia.