Clinical and Experimental Analysis about ABO Hemolytic Disease of the Newborn in Qingdao / 现代检验医学杂志

ABSTRACT

Objective To investigate the clinical and laboratory feature of neonatal hemolytic disease (HDN)occurred in Qingdao caused by mother-baby ABO blood type disagreement.Methods Serum bilirubin (TBIL)test and micro column gel technology were used on 422 cases neonatal hemolytic disease children blood samples (collected from Jun.2013 to Feb.2015).Results There were 388 cases first-born children among 422 cases including 206 cases of type A and 216 of type B and the difference between them was not statistically significant (χ2 =0.24,P >0.05).The difference between male (218 cases)and female (204 cases)was not statistically significant (χ2 =0.24,P >0.05)too.The indirect bilirubin (IBI)increas-ing was more obviously.The peak level of serum bilirubin was 116~465 μmol/L and 256.5~342.0 μmol/L was 38.9% (χ2=0.24,P >0.05).162 cases reticulocyte count was increased nearly 38.5% (χ2 =75.62,P <0.05).RBC antibody release test and serum free antibody test were often positive and the percentage was 80.1% (χ2 =146.98,P <0.05).Conclusion The neonatal hemolytic disease may turn up in first-born children.The child with three positive test was more sensitive to neonatal hyperbilirubinemia.RBC antibody release test and serum free antibody test are often positive.It is important to make the early diagnosis and treatment as soon as possible for reducing the bilirubin encephalopathy.