Expression and functional mechanism of high mobility group A2 in neoplasm / 国际肿瘤学杂志
Journal of International Oncology
; (12): 106-109, 2016.
Article
em Zh
| WPRIM
| ID: wpr-489669
Biblioteca responsável:
WPRO
ABSTRACT
The high mobility group A2 (HMGA2),one of non-histone chromatin protein,can specificly bind to AT-rich DNA sequences by its AT-hook and work as oncofetal gene and architectural transcription factor.HMGA2 expresses in almost all kinds of malignant neoplasms,which is closely related to the formation,development and poor prognosis of the neoplasms.HMGA2 plays a very important role in every biological process including cell proliferation,cell cycle,stem cell self-renewal,epithelial-mesenchymal transition and DNA damage repair.It is of great significance to study the effect and mechanism of HMGA2 in neoplasms.
Texto completo:
1
Base de dados:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article