Expression of c-myc and MDM2 protein in multiple myeloma and their clinical significance / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
; (12): 165-168, 2017.
Article
em Zh
| WPRIM
| ID: wpr-513155
Biblioteca responsável:
WPRO
ABSTRACT
Purpose To investigate the expression of c-myc and MDM2 protein in multiple myeloma (MM) and their correlation with clinical stage.Methods Immunohistochemical SP three-step method was used to detect the expression of MDM2 and c-myc protein in 60 cases of MM with different clinical stages and 10 cases of nontumorous bone marrow tissue.Results The positive rate of c-myc protein in MM and nontumorous bone marrow tissue were 71.7% and 10.0%;the positive rate of MDM2 protein in two tissues were 80.0% and 20.0%,respectively.The expression difference of two proteins between MM and nontumorous bone marrow tissue was statistically significant (P < 0.05).The expression of c-myc and MDM2 protein was positively correlated with MM clinical ISS stage (P < 0.05),but irrelevant with the age and gender.The expression of c-myc and MDM2 protein in MM was positively correlated (P < 0.05).Conclusion The c-myc and MDM2 protein have a highly expression in MM,and it may be relative to the occurrence of MM and clinical stage.In the MM,c-myc and MDM2 protein may have synergetic functions and promote the development of tumor.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article