Effects of Sini decoction on atherosclerosis and ceramide content of aorta in rabbits / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1986.
Article
em Zh
| WPRIM
| ID: wpr-520531
Biblioteca responsável:
WPRO
ABSTRACT
AIM: To observe the effects of Sini decoction on atherosclerosis(AS) and ceramide content of aorta in rabbits. METHODS: 28 rabbits were randomly divided into three groups. Control group was fed with a normal diet; High cholesterol group was fed 1% cholesterol and 5% fat diet; Sini decotion+ high cholesterol group was fed 1% cholesterol and 5% fat diet plus Sini decotion (4.2 g?kg -1 ?d -1 ). At the end of study, the plaque area were measured, the atorta ceramide and cell apoptosis were also detected. RESULTS: Sini decotion diminished lipid plaque area on the aortic endothelium, reduced the levels of aorta ceramide and the apoptosis index. CONCLUSION: Sini decoction has an inhibitory effect on AS, the mechanism may be that Sini decotion reduces concentration of ceramide in aorta.
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Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
1986
Tipo de documento:
Article