THE EXPRESSIONS OF VCAM-1 AND MHC CLASSⅡ MOLECULES IN THE EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS RAT BRAIN VASCULAR ENDOTHELIAL CELLS / 解剖学报
Acta Anatomica Sinica
; (6)1954.
Article
em Zh
| WPRIM
| ID: wpr-570383
Biblioteca responsável:
WPRO
ABSTRACT
Objective To explore the surface molecule changes of the experimental autoimmune encephalomyelitis (EAE) rat brain vascular endothelial cells. Methods The expressions of vascular cell adhesion molecule\|1(VCAM\|1) and major histocompatibility complex (MHC) class Ⅱ molecules in the EAE rat brain vascular endothelial cells were tested by immunohistochemistry. The level of tumor necrosis factor (TNF) and interferon\|?(IFN\|?) in defferent clinic grade EAE were tested by MTT [3\|(4 5\|dimethythiazol\|zyl)\|2^5\|diphenyl) tetrazolium bromide] method. Results There were inducible expressions of VCAM\|1 and MHC class Ⅱ molecules in the EAE rat brain vascular endothelial cells compared with control. The sera of EAE rats possessed the activities of TNF and IFN\|?.Conclusion\ In the CNS inflammation, the change surface molecules in the brain vascular endothelial cells may suggest that it plays important roles in EAE pathogenesis.\;[
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1
Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
1954
Tipo de documento:
Article