Association between a DRD_2 Marker (TaqIA) and Heroin Dependence / 中国心理卫生杂志

ABSTRACT

Objective:to explore the relation of a marker (TaqIA) located DRD 2 gene and heroin dependence.Method:to compare the genotypes and allele frequencies between 66 patients with heroin dependence and 132 normal controls by PCR-RELP. TABPQ was used to measure the characters of patient's behavior.Result:There were significant differences in allele frequencies between patients and controls. No behavior difference was found between patients with different genotypes. Conclusion:There is an association between the marker (TaqIA) and heroin dependence. The data suggest that patients with A1 allele confers susceptibility to heroin dependence.