Detection of Vancomycin-resistant Genes of Enterococcus in Clinic and Their Molecular Epidemiology / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the sensitivity to vancomycin of Enterococcus in clinic and the genotype and homology of glycopeptides-resistant strains.METHODS The sensitivity to vancomycin in 72 enterococci strains was detected with agar dilution;the existence of vanA,vanB,vanC1 and vanC2 in enterococci was detected by PCR and ERIC-PCR.RESULTS More than 50% of enterococci intermediated to vancomycin were resistant to other antimicrobial agents commonly used in clinic,except for teicoplanin and linezolid.Gene of vanC2 was present in two strains,but none with vanA and vanB.The ten strains of enterococci intermediated to vancomycin were divided into eight types,in which type A(3 strains) was isolated from the same hospital.CONCLUSIONS Multidrug resistance is observed in enterococci resistant to vancomycin,which are sensitive to teicoplanin and linezolid.Gene of vanC2 is found in some of them,suggesting clone transmission happen among strains.