EFFECTS OF TETRAMETHYLPYRAZINE ON RETINA OF RABBITS WITHEXPERIMENTAL GLAUCOMA / 药物分析学报
Journal of Pharmaceutical Analysis
; (6): 23-26,45, 2000.
Article
em Zh
| WPRIM
| ID: wpr-623142
Biblioteca responsável:
WPRO
ABSTRACT
Objective To observe the effects of tetramethyipyrazine(TMP) on retina to find out whether it can protect retina from glaucomatous damage. Methods Twenty-four rabbits were randomly divided into four groups. One eye of each rabbit was model eye induced by 2% methylcellulous, and the other was control eye. Normal saline, TMP, timolol and a combination of timolol and TMP were administrated to group A, B, C and D respectively. At the end of 4th week, eyes were excavated for light and electron microscopic study. Results The numbers of ganglion cells (P <0. 01) and bipolar cells (P <0. 01) in model eye were different significantly between group A and B. In group A, the model eye ganglion cells were karyopyknosis, chromatin margination and nuclear membrane rupture; some in ner nuclear cells dcveloped marked lytic changes; outer segment appeared disorganized; but group B changed slight ly. Conclusion The results suggest that TMP may protect retina from glaucomatous damage.
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Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2000
Tipo de documento:
Article