A Study on Mitomycin C Induced Damage to the Iris and Ciliary Body of Cats
Journal of the Korean Ophthalmological Society
; : 486-491, 1995.
Article
em Ko
| WPRIM
| ID: wpr-63455
Biblioteca responsável:
WPRO
ABSTRACT
This study was performed to investigate the toxicity of mitomycin C(MMC) on the iris and ciliary body of the cat. After anesthesia, MMC in 0.1, 0.2, or 0.4 mg/ml concenration was injected intracamerally and the equal volume of balanced salt solution(BSS) was injected intracamerally to the contralateral eye as a control. There were no significant difference between 0.1 mg/ml of MMC and BBS injection except for the enlargement of endoplasmic reticulum and destruction of cristae of ciliary body 14 days after MMC injection. Iris vessel was congested and mitochondria of ciliary body was enlarged and cristae was disrupted 7 days after 0.4 mg/ml of MMC injection. There were infiltration of inflammatory cell on the iris and increased cellular damage at the nonpigmented epithelium of ciliary body 21 days after 0.4 mg/ml of MMC injection. These results suggest that the caution is necessary to prevent high concentration of MMC from getting into the anterior chamber at the time of glaucoma filtering surgery in human.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Glaucoma
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Iris
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Corpo Ciliar
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Mitomicina
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Estrogênios Conjugados (USP)
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Cirurgia Filtrante
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Retículo Endoplasmático
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Epitélio
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Anestesia
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Câmara Anterior
Limite:
Animals
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Humans
Idioma:
Ko
Ano de publicação:
1995
Tipo de documento:
Article