Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia
Korean Journal of Urology
; : 565-571, 2015.
Article
em En
| WPRIM
| ID: wpr-65718
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). MATERIALS AND METHODS: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups-patients with and without HGPIN-and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. RESULTS: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p<0.001) was associated with BCR. CONCLUSIONS: PCa patients with HGPIN have a higher Gleason score, more frequent multiple tumors, and more perineural invasion than those without HGPIN. The presence of HGPIN is not an independent predictor of BCR.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Nervos Periféricos
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Prognóstico
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Prostatectomia
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Neoplasias da Próstata
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Recidiva
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Estudos Retrospectivos
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Neoplasia Prostática Intraepitelial
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Gradação de Tumores
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Metástase Linfática
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Invasividade Neoplásica
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Aged
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article