Inhibitory mechanisms of diazepam on macroscopic sodium currents in rat sympathetic ganglion neurons / 中国临床药理学与治疗学
Article
em Zh
| WPRIM
| ID: wpr-677377
Biblioteca responsável:
WPRO
ABSTRACT
Aim The effects of diazepam on the whole cell sodium currents in rat sympathetic ganglion neurons were studied to investigate the mechanisms by diazepam mediates hypotension. Methods Whole cell patch clamp recordings were performed on enzymatically isolated rat superior cervical sympathetic ganglion neurons. Results Diazepam dose dependently blocked the whole cell sodium currents. Under a V t of 0 mV and a V h of 80 mV 0.3 ?mol?L -1 diazepam reduced sodium peak currents by 14.76 %(P
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1
Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2000
Tipo de documento:
Article