Research advances in the role of aptamers in the diagnosis and targeted therapy of pediatric cancer / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 421-427, 2018.
Article
em Zh
| WPRIM
| ID: wpr-689614
Biblioteca responsável:
WPRO
ABSTRACT
Aptamers are single-stranded DNA or RNA which are isolated from synthesized random oligonucleotide library in vitro via systematic evolution of ligands by exponential enrichment (SELEX) and can bind to metal ions, small molecules, carbohydrates, lipids, proteins, and others targets with high affinity and specificity. Aptamers have the advantages of simple preparation, good thermal stability, and low immunogenicity and have great potential in the medical fields such as molecular imaging, biosensing, early diagnosis of diseases, and targeted therapy. Aptamer technology may be useful for early diagnosis and targeted therapy of pediatric cancer, and may avoid the side effects of conventional chemotherapy, such as growth and development disorders and long-term organ dysfunction. This article reviews the latest research advances in the selection and application of aptamers for pediatric cancer.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Diagnóstico
/
Tratamento Farmacológico
/
Técnica de Seleção de Aptâmeros
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Detecção Precoce de Câncer
/
Terapia de Alvo Molecular
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Métodos
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Child
/
Humans
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article