In Vitro Angiogenesis Effect of Xuefu Zhuyu Decoction () and Vascular Endothelial Growth Factor: A Comparison Study / 中国结合医学杂志
Chinese journal of integrative medicine
; (12): 606-612, 2018.
Article
em En
| WPRIM
| ID: wpr-691401
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the angiogenesis behaviors of vascular endothelial growth factor (VEGF) and Chinese medicine Xuefu Zhuyu Decoction (, XZD) treatments.</p><p><b>METHODS</b>Human microvascular endothelial cells (HMEC-1) were treated with various concentrations of either XZD-containing serum (XZD-CS) or VEGF for 24, 48, and 72 h, respectively. Cell viability, proliferation, migration, adhesion, and in vitro tube formation assays were used to assess their angiogenic effects.</p><p><b>RESULTS</b>VEGF promoted all cellular phases involved in angiogenesis including cell viability, proliferation, migration, adhesion, and tube formation (<0.05 or <0.01). Unlike the continuous promotion effects of VEGF at the above stages, XZD inhibited cell viability and proliferation (<0.05 or <0.01) and only promoted tube formation in the early phase of angiogenesis (<0.01).</p><p><b>CONCLUSIONS</b>These two medications promote different angiogenesis behaviors, which might be an important reason for their distinct therapeutic profile in clinical usage.</p>
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Medicamentos de Ervas Chinesas
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Adesão Celular
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Ciclo Celular
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Linhagem Celular
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Movimento Celular
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Sobrevivência Celular
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Neovascularização Fisiológica
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Biologia Celular
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Células Endoteliais
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article