Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics
Journal of the Korean Association of Oral and Maxillofacial Surgeons
; : 66-72, 2018.
Article
em En
| WPRIM
| ID: wpr-714257
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. MATERIALS AND METHODS: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method. RESULTS: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%. CONCLUSION: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Recidiva
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Vimentina
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Taxa de Sobrevida
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Intervalo Livre de Doença
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Diagnóstico
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Erros de Diagnóstico
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Melanoma
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Métodos
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Boca
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article