BDNF Methylation and Suicidal Ideation in Patients with Acute Coronary Syndrome
Psychiatry Investigation
; : 1094-1097, 2018.
Article
em En
| WPRIM
| ID: wpr-718359
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: Patients with acute coronary syndrome (ACS) are at an increased risk of suicide. It is well known that epigenetic mechanisms may explain the pathophysiology of suicidal behavior including suicidal ideation (SI), but no study has explored these mechanisms in ACS populations. METHODS: In total, 969 patients were initially recruited within 2 weeks of the acute coronary event and, 711 patients were successfully followed up 1 year after ACS. SI was evaluated using the relevant items on the Montgomery-Åsberg Depression Rating Scale and covariates potentially affecting SI were estimated. RESULTS: Brain-derived neurotrophic factor (BDNF) hypermethylation was associated with SI in both the acute and chronic phases of ACS, although the association was not statistically significant in the acute phase after applying Bonferroni’s correction. CONCLUSION: These results suggested that BDNF hypermethylation may have played a role in an epigenetic predisposition for SI in ACS patients, particularly during the chronic phase.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Suicídio
/
Estudos Longitudinais
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Fator Neurotrófico Derivado do Encéfalo
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Depressão
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Síndrome Coronariana Aguda
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Ideação Suicida
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Epigenômica
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Metilação
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article