Effect of Antipsychotic Drugs on Dopamine Transporter Function in CV(bDAT) Cells
Journal of the Korean Society of Biological Psychiatry
; : 48-53, 1997.
Article
em Ko
| WPRIM
| ID: wpr-724916
Biblioteca responsável:
WPRO
ABSTRACT
CV(bDAT) cell line, expressing dopamine transporter stably, has been established by transfection of CV-1 cells with bovine dopamine transporter cDNA. Using CV(bDAT) cells, the effects of various antipsychotic drugs on dopamine uptake were investigated. All of antipsychotic drugs tested, inhibited the [3>H]dopamine uptake into CV(bDAT) cells with IC50s in the low to mid micromolar, implying that antipsychotic drugs may produce overflow of dopamine in the synaptic cleft of dopaminergic neuron.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Antipsicóticos
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Transfecção
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Dopamina
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Linhagem Celular
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DNA Complementar
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Concentração Inibidora 50
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Proteínas da Membrana Plasmática de Transporte de Dopamina
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Neurônios Dopaminérgicos
Idioma:
Ko
Ano de publicação:
1997
Tipo de documento:
Article