Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase
The Korean Journal of Physiology and Pharmacology
; : 123-128, 2011.
Article
em En
| WPRIM
| ID: wpr-727892
Biblioteca responsável:
WPRO
ABSTRACT
Caesalpinia sappan (C. sappan) is a medicinal plant used for promoting blood circulation and removing stasis. During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of C. sappan (CLE) showed inhibitory activity on arginase which has recently been reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. CLE inhibited arginase II activity prepared from kidney lysate in a dose-dependent manner. In HUVECs, inhibition of arginase activity by CLE reciprocally increased NOx production through enhancement of eNOS dimer stability without any significant changes in the protein levels of eNOS and arginase II expression. Furthermore, CLE-dependent arginase inhibition resulted in increase of NO generation and decrease of superoxide production on endothelium of isolated mice aorta. These results indicate that CLE augments NO production on endothelium through inhibition of arginase activity, and may imply their usefulness for the treatment of cardiovascular diseases associated with endothelial dysfunction.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Aorta
/
Arginase
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Plantas Medicinais
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Circulação Sanguínea
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Doenças Cardiovasculares
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Programas de Rastreamento
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Superóxidos
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Caesalpinia
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Endotélio
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Aterosclerose
Tipo de estudo:
Screening_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article