Regulation of Allergic Immune Responses by Microbial Metabolites
Immune Network
; : e15-2018.
Article
em En
| WPRIM
| ID: wpr-740197
Biblioteca responsável:
WPRO
ABSTRACT
Emerging evidence demonstrates that the microbiota plays an essential role in shaping the development and function of host immune responses. A variety of environmental stimuli, including foods and commensals, are recognized by the host through the epithelium, acting as a physical barrier. Two allergic diseases, atopic dermatitis and food allergy, are closely linked to the microbiota, because inflammatory responses occur on the epidermal border. The microbiota generates metabolites such as short-chain fatty acids and poly-γ-glutamic acid (γPGA), which can modulate host immune responses. Here, we review how microbial metabolites can regulate allergic immune responses. Furthermore, we focus on the effect of γPGA on allergic T helper (Th) 2 responses and its therapeutic application.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Acessibilidade Arquitetônica
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Dermatite Atópica
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Epitélio
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Células T Matadoras Naturais
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Ácidos Graxos Voláteis
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Microbiota
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Hipersensibilidade Alimentar
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article