Cytotoxic Lactones from the Pericarps of Litsea japonica
Natural Product Sciences
; : 23-27, 2019.
Article
em En
| WPRIM
| ID: wpr-741649
Biblioteca responsável:
WPRO
ABSTRACT
From the pericarps of Litsea japonica (Thunb.) Jussieu, eighteen butanolide derivatives (1 – 18) were evaluated for their cytotoxic activity against HeLa, HL-60, and MCF-7 cells. Compounds 1 – 9 with 2-alkylidene-3-hydroxy-4-methylbutanolides structure exhibited cytotoxic activities against cancer-cell lines. Among them, compound 8 (litsenolide D₂) exhibited the most potent cytotoxicity against the tested cell lines, including HeLa, HL-60, and MCF-7, with IC₅₀ values of 17.6 ± 1.3, 4.2 ± 0.2, and 12.8 ± 0.0 µM, respectively. Compound 8 induced apoptosis in a dose-dependent manner. Annexin V/Propidium Iodide (PI) double staining confirmed that 8 effectively induced apoptosis in MCF-7 cells. To the best of our knowledge, we have reported cytotoxic activity of butanolides from L. japonica against these cancer-cell lines for the first time.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Linhagem Celular
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Apoptose
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Lauraceae
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Litsea
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Células MCF-7
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Lactonas
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article