Fasting serum C-peptide is useful for initial classification of diabetes mellitus in children and adolescents
Annals of Pediatric Endocrinology & Metabolism
; : 80-85, 2014.
Article
em En
| WPRIM
| ID: wpr-7428
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
With rising obesity rates in children, it is increasingly difficult to differentiate between type 1 and type 2 diabetes mellitus (T1DM, T2DM) on clinical grounds alone. Using C-peptide as a method of classifying diabetes mellitus (DM) has been suggested. This study aimed to find a correlation between fasting C-peptide level and DM types in children and adolescents.METHODS:
A total of 223 diabetic children, newly diagnosed at 5 hospitals between January 2001 and December 2012, were enrolled in this study. Initial DM classification was based on clinical and laboratory data including fasting C-peptide at diagnosis; final classification was based on additional data (pancreatic autoantibodies, human leukocyte antigen type, and clinical course).RESULTS:
Of 223 diabetic children, 140 were diagnosed with T1DM (62.8%) and the remaining 83 with T2DM (37.2%). The mean serum C-peptide level was significantly lower in children with T1DM (0.80 ng/mL) than in children with T2DM (3.91 ng/mL). Among 223 children, 54 had a serum C-peptide level 3.0 ng/mL; 48 of them (97.9%) were diagnosed with T2DM.CONCLUSION:
In this study, we found that if the C-peptide level was 3.0 ng/mL, a T1DM diagnosis is unlikely. This finding suggests that serum fasting C-peptide level is useful for classifying DM type at the time of diagnosis in youth.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Autoanticorpos
/
Peptídeo C
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Jejum
/
Classificação
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Diabetes Mellitus
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Diabetes Mellitus Tipo 2
/
Diagnóstico
/
Leucócitos
/
Obesidade
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Child
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article