Research progress of aspartyl-(asparaginyl) β-hydroxylase in hepatocellular carcinoma / 中华肝胆外科杂志

ABSTRACT

Hepatocellular carcinoma is characterized by a high rate of incidence,along with significant likelihood of postoperative recurrence and metastatic,whereas its underlying mechanism remains considerably unclear.The overexpression of Aspartyl/Asparaginyl beta-hydroxylase (ASPH,AAH) was initially found in hepatocellular carcinoma and cholangiocarcinoma,signifying its involving in multiple biological behaviors of hepatocellular carcinoma.Here we review recent advances on ASPH in hepatocellular carcinoma,aiming to provide a new theoretical basis for its treatment prospectively.