Analysis of nasal clinical manifestations and treatment of granulomatosis with polyangiitis / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To raise awareness of granulomatosis with polyangiitis by summarizing its nasal mani- festations and treatment experience.@*METHOD@#Retrospective studies were done to the nasal clinical manifestations and treatment processes of 21 GPA patients in this study. All were treated by the combined treatment of glucocorticoid, cyclophosphamide as well as tripterygium wilfordii, and 4 of them who had much heavier nasal symptoms were treated by endoscopic sinus operation at the same time.@*RESULT@#Eighteen cases were effective treated by medical treatments besides 3 were died of all 21 cases. The nasal symptoms of those 4 patients were obviously improved, and still had effective drainage of sinus after operation with 8-22 months follow up, although the sinus ostiums were reduced comparing to themselves intraoperation at different degree.@*CONCLUSION@#GPA is always been ignored which will lead to delay treatment due to the lack of specificity of its clinical manifestations. So, enough attention is the key point of avoiding misdiagnosis as well as providing timely treatment for these patients.